Search for dissertations about: "lactam"

Showing result 1 - 5 of 47 swedish dissertations containing the word lactam.

  1. 1. On the Versatility of Microwave-Assisted Chemistry Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kristina M. Orrling; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; Biochemistry; biokemi;

    Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

  2. 2. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors Microwave Applications in Batch and Continuous Flow Organic Synthesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Per Öhrngren; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. READ MORE

  3. 3. Neurotoxicity of β-lactam antibiotics experimental kinetic and neurophysiological studies

    University dissertation from Umeå : Umeå universitet

    Author : Silvia E. Schliamser; Umeå universitet.; [1988]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

    Abstract : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. READ MORE

  4. 4. Some New Methods in Sialic Acid Chemistry

    University dissertation from Organic Chemistry, Lund University

    Author : Teddy Ercegovic; Lunds universitet.; Lund University.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; thioglycoside promoter; ganglioside; Tumor-associated antigen; lactam; lactone; sialic acid; N-acetylneuraminic acid; Neu5Ac; sialyl donor; auxiliary group; 3- S -phenylthio; bis-sialic acid lactam; 3- S -phenylseleno; silver trifluoromethanesulfonate; iodine monochloride; Organic chemistry; Organisk kemi;

    Abstract : Gangliosides (G) are sialic acid-containing cell surface glycosphingolipids capable of forming lactones, i.e. inner esters. Some gangliosides are tumor-associated antigens, and they may serve as immunogens in their lactone form, where the latter is comparatively more abundant on the surface of malignant cells. READ MORE

  5. 5. Haemophilus influenzae – typing, epidemiology and beta-lactam resistance

    University dissertation from Lund University, Faculty of Medicine

    Author : Viktor Månsson; Lunds universitet.; Lund University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; beta-lactam resistance; beta-lactams; BLNAR; capsule typing; clonal; Haemophiilus influenzae; Hib; MALDI-TOF MS; MLST; NTHi; serotyping; virulence; epidemiology;

    Abstract : Haemophilus influenzae är en bakterie som lever i människans luftvägar. Ofta orsakar bakterien ingen skada hos personen som bär den, men ibland orsakar H. influenzae luftvägsinfektioner såsom öroninflammation hos barn, akut försämring hos patienter med kroniskt obstruktiv luftvägssjukdom (KOL) samt lunginflammation. READ MORE