Search for dissertations about: "lamivudine"

Showing result 1 - 5 of 12 swedish dissertations containing the word lamivudine.

  2. 1. Drug Analysis : Bioanalytical Method Development and Validation

    Author : Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  4. 2. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Author : Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. READ MORE

  5. 3. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus

    Author : Sebastian Malmström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; real-time PCR; lamivudine resistance; genotypes; replication;

    Abstract : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. READ MORE

  6. 4. Resistance to antiviral drugs in HIV and HBV

    Author : Anna Lindström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; HBV; drug-resistance; Sanger sequencing; pyrosequencing;

    Abstract : Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for treatment failure, but may also develop secondary to problems with adherence or pharmacokinetics. READ MORE

  7. 5. Resolution of Dynamic Systems: Applications in Asymmetric Synthesis and Materials Science

    Author : Lei Hu; Olof Ramström; Douglas Philp; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

    Abstract : This thesis is built on the concepts of constitutional dynamic chemistry and dynamic kinetic resolution, where reversible covalent reactions are used to generate dynamics and kinetically controlled reactions are employed for resolution. The thesis is divided into two parts:The first section focuses on the study of dynamic systemic resolution, a concept derived from constitutional dynamic chemistry. READ MORE