Search for dissertations about: "lc-ms method development and method validation thesis"

Found 5 swedish dissertations containing the words lc-ms method development and method validation thesis.

2. 1. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

   Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE

4. 2. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

   Author : Joel Tärning; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

   Abstract : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. READ MORE

5. 3. Development of analytical methods for the determination of the small molecule component of complex biological systems

   Author : Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Abstract : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. READ MORE

6. 4. Development and application of an LC-MS method for the alcohol biomarker phosphatidylethanol (PEth) in blood

   Author : Yufang Zheng; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Objective biomarkers tracing alcohol consumption are demanded in many situations when alcohol drinking is in focus, e.g. during monitoring of patient in a treatment program, in forensic medicine, workplace testing or biochemical validation of self-report in research. READ MORE

7. 5. At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation

   Author : Fabio Socciarelli; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have raised more questions than given answers. READ MORE