Search for dissertations about: "lc3"
Showing result 1 - 5 of 14 swedish dissertations containing the word lc3.
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1. Protein expression and modifications in denervated atrophic and hypertrophic skeletal muscle
Abstract : Skeletal muscle comprises about 45% of the total body weight. It is the largest tissue in the body, vital for maintaining posture, produce locomotion, breathing but also functions as a large reservoir of proteins. READ MORE
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2. Modulation of PDGF receptors function by posttranslational modifications
Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE
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3. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease
Abstract : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. READ MORE
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4. The role of autophagy in anticancer therapy
Abstract : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. READ MORE
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5. Mechanisms of HAMLET-induced cancer cell death
Abstract : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. READ MORE