Search for dissertations about: "leucine-rich repeat"

Showing result 21 - 25 of 30 swedish dissertations containing the words leucine-rich repeat.

  2. 21. Interactions between extracellular matrix proteins and the complement system - In the perspective of cartilage degradation in inflammatory joint diseases

    Author : Camilla Melin Fürst; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; rheumatoid arthritis; osteoarthritis; extracellular matrix; cartilage degradation; mass spectrometry;

    Abstract : Abstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role in promoting the joint inflammation in these diseases. READ MORE

  4. 22. Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development

    Author : Annelie Shami; Kärlväggsbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; fibromodulin; dystrophin; carotid artery; lipid accumulation; restenosis; plaque;

    Abstract : Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. READ MORE

  5. 23. Defense gene responses toward necrotrophic fungi in Arabidopsis thaliana

    Author : Hanneke Marjolijn Peele; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Leptosphaeria maculans an ascomycete in the diverse class of Dothideomycetes, is an devastating pathogen on Brassica crops. In this thesis, tools and knowledge in Arabidopsis thaliana was explored to enhance our knowledge on plant defense to this fungus. Mechanisms that to large extent are shared with other necrotrophic fungi. READ MORE

  6. 24. Neurodegenerative diseases studied in human brain and rodent models

    Author : Sandra Gellhaar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s and Alzheimer’s disease are the two most common neurodegenerative diseases world-wide, but are still little understood. Papers in this thesis examine some of the possible pathogenic mechanisms with the help of mouse models and analysis of human post-mortem tissue. READ MORE

  7. 25. Stem cells and development : studies on SUFU and LGR5

    Author : Maria Hölzl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT signalling cascades play key roles in a variety of developmental processes where deregulation of these pathways result in a diversity of birth defects. READ MORE