Search for dissertations about: "leukemia thesis"

Showing result 1 - 5 of 385 swedish dissertations containing the words leukemia thesis.

  1. 1. IKAROS and LEUKEMIA

    University dissertation from Division of Clinical Genetics, Lund University

    Author : Linda Olsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric acute lymphoblastic leukemia; relapse; risk-stratifying factors; IKZF1; cooperative changes;

    Abstract : Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. READ MORE

  2. 2. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry

    University dissertation from Division of Clinical Genetics, Lund University

    Author : Lovisa Vennström; Göteborgs universitet.; Gothenburg University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; population-based; incidence; survival; acute myeloid leukemia; acute lymphoblastic leukemia; acute promyelocytic leukemia; early death;

    Abstract : Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. READ MORE

  3. 3. Immunotherapy and immunosuppression in myeloid leukemia

    University dissertation from Division of Clinical Genetics, Lund University

    Author : Alexander Hallner; Göteborgs universitet.; Gothenburg University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; acute myeloid leukemia; histamine dihydrochloride; immunotherapy; reactive oxygen species; chronic myelomonocytic leukemia; NK cell education; NKG2A; HLA; KIR;

    Abstract : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. READ MORE

  4. 4. Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis

    University dissertation from Division of Clinical Genetics, Lund University

    Author : Anna Staffas; Göteborgs universitet.; Gothenburg University.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prognostic markers; AML; T-ALL; leukemia; FLT3; NPM1; ERG; BAALC; KRAS;

    Abstract : Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. However, patients with a certain subtype of leukemia (e.g. READ MORE

  5. 5. The role of the leukemia-associated ETO homologue repressors in hematopoiesis

    University dissertation from Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University

    Author : André Olsson; Lund University.; Lunds universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MTGR1; ETO; MTG16; AML1-ETO; hematopoiesis; leukemia; diffferentiation; extracellular fluids; Haematology; Medicin människa och djur ; extracellulära vätskor; Hematologi; Medicine human and vertebrates ;

    Abstract : The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. READ MORE