Search for dissertations about: "leukotriene B4"

Showing result 1 - 5 of 39 swedish dissertations containing the words leukotriene B4.

2. 1. Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1

   Author : Alan Sabirsh; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; fluidity; redox; chemotaxis; luciferase; calcium; ligand binding; point mutation; modelling; antibody; BLT1; leukotriene; pharmacology; GPCR; G-protein; receptor;

   Abstract : Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. READ MORE

4. 2. Biosynthesis of leukotriene B4 in hematological malignancies

   Author : Gudmundur Runarsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : LTB 4; 5-LO; cPLA 2; iPLA 2; AML; B-ALL; B-CLL;

   Abstract : Leukotrienes (LT) are biologically active metabolites of the fatty acid arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA 2), this fatty acid can be converted to leukotrienes, lipoxins, prostaglandins or thromboxane. The conversion of AA to LTA 4 is catalyzed by five-lipoxygenase (5-LO). READ MORE

5. 3. Studies on leukotriene B4 and alarmins in inflammatory responses

   Author : Min Wan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong to the alarmin family known to promote innate and adaptive immune reactions in response to tissue infection or injury. READ MORE

6. 4. Innate defense mechanisms of the nasal airway

   Author : Henrik Widegren; Lund näs- och halssjukdomar Öron-; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; Leukotriene B4; CC10; TNF-alpha; innate immunity; allergic rhinitis; Airway inflammation;

   Abstract : Allergic and infectious rhinitis are prevalent conditions that besides a direct morbidity also causes exacerbations of asthma and chronic obstructive pulmonary disease. The immune mechanisms associated with various forms of rhinitis are not fully understood. READ MORE

7. 5. Intrafollicular pressure and biochemical mediators in ovulation

   Author : Markus Matousek; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovulation; protein tyrosine kinase; ovulation; leukotriene B4; intrafollicular pressure; contractions and smooth muscle cell.;

   Abstract : Ovulation is the process whereby the preovulatory follicle ruptures to enable a fertilisable ovum to escape from the interior of the ovary to the oviduct. During the ovulatory process, from he onset of the preovulatory LH-surge to the follicular rupture, marked biochemical and structural changes in follicles to enable it to rupture. READ MORE