Search for dissertations about: "leukotriene receptor antagonists"

Showing result 1 - 5 of 10 swedish dissertations containing the words leukotriene receptor antagonists.

  2. 1. Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases

    Author : Hong Qiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotrienes (LTs) are a family of lipid mediators that are involved in host defense and inflammatory responses. They are synthesized from arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are divided into two classes, the classical chemoattractant leukotriene B4 (LTB4), and spasmogenic cysteinyl leukotrienes (cys-Us) including LTC4, LTD4 and LTE4. READ MORE

  4. 2. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Author : Sailaja Paruchuri; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Abstract : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. READ MORE

  5. 3. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    Author : Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Abstract : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. READ MORE

  6. 4. Eicosanoids in cancer : new therapeutic targets in neuroblastoma

    Author : Agnes Rasmuson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is one of the most common causes of death for both children and adults in developed countries. Neuroblastoma is a cancer of the sympathetic nervous system that affects infants and young children. Neuroblastoma tumors are the most common solid extracranial tumors in children and are also the most deadly. READ MORE

  7. 5. Experimental studies of lipid mediator modulation of airway responsiveness

    Author : Willem Abma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lipid mediators play an important role in responsiveness of the airways. The roles of prostanoids and leukotrienes in inducing airway inflammation and contraction are reasonably well established. READ MORE