Search for dissertations about: "library medical"

Showing result 11 - 15 of 109 swedish dissertations containing the words library medical.

  2. 11. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

    Author : Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. READ MORE

  4. 12. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum

    Author : Dimitra Lappa; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; Obesity; multi-omics integration; biomarkers; gallstones; non-alcoholic fatty liver disease; GPCR receptors; metabotyping; bariatric surgery; self-organizing maps;

    Abstract : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. READ MORE

  5. 13. Studies on the Differential Specificity of Protein Kinases and Its Applications

    Author : Mart Loog; Bengt Jergil; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Protein kinases; protein kinase inhibitors; substrate specificity; peptide libraries; affinity chromatography; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Protein kinases are enzymes that catalyse the phosphoryl transfer from the g-phosphate of ATP to acceptor amino acids in proteins. The specificity of selected model protein kinases was studied at three different levels using a) novel bi-substrate-analogue inhibitors, b) synthetic peptide substrates and c) mutated protein substrate analogues. READ MORE

  6. 14. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications

    Author : Mikael Åstrand; Sophia Hober; John Löfblom; Larry Gold; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Protein G; ERBB2; ERBB3; Directed evolution; phage display; staphylococcal display; bispecific; Bioteknologi; Biotechnology;

    Abstract : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. READ MORE

  7. 15. Characterization of the DNA-Binding Properties of the Cyanobacterial Transcription Factor NtcA

    Author : Susanne Wisén; Bengt Mannervik; Enrique Flores; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; NtcA; transcription regulation; cyanobacteria; redox regulation; DNA binding; nitrogen fixation; Anabaena PCC 7120; Biokemi; Biochemistry; Biokemi;

    Abstract : Nitrogen is an essential building block of proteins and nucleic acids and, therefore, crucial for the biosphere. Nearly 79 % of the air consists of nitrogen, but in the form of nitrogen gas (N2), which cannot be utilized by most organisms. READ MORE