Search for dissertations about: "ligand distribution"

Showing result 11 - 15 of 91 swedish dissertations containing the words ligand distribution.

  2. 11. Multiple Functions of Glutathione Transferases : A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

    Author : Maryam Edalat; Joseph De Pierre; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a proper protection system. Glutathione transferases (GSTs) are important components of the cellular defense against oxidative stress. These proteins appear to be suited for different tasks. READ MORE

  4. 12. Homogeneous and heterogeneous Cp*Ir(III) catalytic systems : Mechanistic studies of redox processes catalyzed by bifunctional iridium complexes, and synthesis of iridium-functionalized MOFs

    Author : Greco González Miera; Belén Martín-Matute; Matt Clarke; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; catalysis; bifunctional; metal-ligand cooperation; amine alkylation; Hammett; kinetics; acceptorless alcohol dehydrogenation; MOF; transition metal; synchrotron; organisk kemi; Organic Chemistry;

    Abstract : The purpose of this doctoral thesis is to investigate and develop catalytic processes mediated by iridium(III) complexes. By understanding the mechanisms, the weaknesses of the designed catalysts can be identified and be overcome in the following generation. READ MORE

  5. 13. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Author : Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Abstract : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. READ MORE

  6. 14. Synthesis of donor–acceptor–donor thiophene based ligands that can be utilized for optical assignment of pathological targets

    Author : Linda Lantz; Peter Nilsson; Peter Konradsson; Jerker Mårtensson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Thiophene based ligands represent a class of molecular reporters proven superior in discerning pathological targets involved in neurodegenerative diseases, as well as bacterial infection. By fluorometric detection that depends on the milieu surrounding the ligand these biological processes can be studied with fluorescence spectroscopy and hyper-spectral confocal microscopy. READ MORE

  7. 15. Theoretical Studies of Drug-Metabolizing Cytochrome P450 Enzymes

    Author : Junhao Li; Yaoquan Tu; Ulf Ryde; KTH; []
    Keywords : Cytochrome P450 enzymes; molecular dynamics; quantum chemistry; structural flexibililty; ONIOM; Teoretisk kemi och biologi; Theoretical Chemistry and Biology;

    Abstract : The family of cytochrome P450 enzymes (P450s) belongs to one of the most important enzyme families in the human body. P450s are involved in the synthesis of endogenous compounds and metabolism of exogenous substances. READ MORE