Search for dissertations about: "ligand"

Showing result 6 - 10 of 1321 swedish dissertations containing the word ligand.

  2. 6. Infrared spectroscopy : Method development and ligand binding studies

    Author : Saroj Kumar; Andreas Barth; Janos Mink; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Infrared; Ligand binding; method development; Biophysical chemistry; Biofysikalisk kemi; biofysik; Biophysics;

    Abstract : Infrared spectroscopy detects molecular vibrations and assesses the properties of molecules and their environment. It is a powerful technique to detect ligand induced changes in biomolecules as it has distinct signals and provides different levels of structural information. READ MORE

  4. 7. Ligand Substitution and Solvent : Exchange Reactions of Palladium(II) and Platinum(II) Acetonitrile and Dimethyl Sulfoxide Complexes. A High-Pressure Stopped-Flow and NMR Study

    Author : Björn Hellquist; Jönköping University; []
    Keywords : ;

    Abstract : .... READ MORE

  5. 8. The circular dichroism of DNA-ligand systems

    Author : Reidar Lyng; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 6-diamidino-2-phenylindole; transition moments; methylene blue; optical activity; DNA ligand; DNA; induced circular dichroism; calculation of circular dichroism; Ru 1; circular dichroism; 10-phenathroline ; 4 ;

    Abstract : .... READ MORE

  6. 9. Theoretical studies of protein-ligand binding

    Author : Majda Misini Ignjatovic; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP;

    Abstract : Understanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. READ MORE

  7. 10. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions

    Author : David Andersson; Anna Linusson Jonsson; Gabriele Cruciani; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; Pharmaceutical chemistry; Läkemedelskemi; datorlingvistik; computational linguistics;

    Abstract : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. READ MORE