Search for dissertations about: "ligase"

Showing result 1 - 5 of 100 swedish dissertations containing the word ligase.

  1. 1. Ligation-mediated Molecular Analysis of Influenza Subtypes, Splicing and Protein Glycosylation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tim Conze; Uppsala universitet.; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ligase; proximity ligation; gastric cancer; glycosylation; alternative splicing; avian influenza; padlock probe; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Molecular medicine genetics and pathology ; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

    Abstract : Binder-based assays are employed throughout the life sciences. Powerful signal amplification techniques have enabled detection of very rare molecule species diluted in simple buffers. Unspecific binding of primary binders leads to increased background in more complex samples. READ MORE

  2. 2. A study on the E3 ligase TRIM21/Ro52

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Alexander Espinosa; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti- TRIM21/Ro52 autoantibodies is used as a diagnostic tool, the biological function of TRIM21/Ro52 is still unknown. READ MORE

  3. 3. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Aurélie Ambrosi; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. READ MORE

  4. 4. Markers predicting sensitivity to polyamine depletion in human breast cancer cell lines

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Veronica Johansson; Lunds universitet.; Lund University.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PCNA; PAO; human breast cancer cell lines; FEN1; DNA strand breaks; DNA ligase I; apoptosis; Bcl-2; polyamine analogues; pRb;

    Abstract : In spite of different treatment strategies today, breast cancer mortality is still high and new treatments are therefore needed. Potential new treatments can be found among the polyamine analogues. Polyamine analogues can be used in cancer treatment as cancer cells have a higher requirement for polyamines than the surrounding healthy tissue. READ MORE

  5. 5. Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge

    University dissertation from Göteborg : University of Gothenburg

    Author : Lars Lundvik; Göteborgs universitet.; Gothenburg University.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amino acid tRNA ligase; analytical ultracentrifugation;

    Abstract : ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, gel electrophoresis, gel chromatography were used in these investigations. READ MORE