Search for dissertations about: "ligase"

Showing result 6 - 10 of 115 swedish dissertations containing the word ligase.

  2. 6. Markers predicting sensitivity to polyamine depletion in human breast cancer cell lines

    Author : Veronica Johansson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PCNA; PAO; human breast cancer cell lines; FEN1; DNA strand breaks; DNA ligase I; apoptosis; Bcl-2; polyamine analogues; pRb;

    Abstract : In spite of different treatment strategies today, breast cancer mortality is still high and new treatments are therefore needed. Potential new treatments can be found among the polyamine analogues. Polyamine analogues can be used in cancer treatment as cancer cells have a higher requirement for polyamines than the surrounding healthy tissue. READ MORE

  4. 7. Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge

    Author : Lars Lundvik; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amino acid tRNA ligase; analytical ultracentrifugation;

    Abstract : ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, gel electrophoresis, gel chromatography were used in these investigations. READ MORE

  5. 8. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

    Author : Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

    Abstract : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. READ MORE

  6. 9. Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases

    Author : Janosch Hennig; Maria Sunnerhagen; Kylie J. Walters; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Abstract : Several members of the tripartite motif (TRIM) protein family are involvedin antiviral activity and immunity and have been linked to severaldiseases. TRIM21, the main object of this thesis, is involved in Sjögrensyndrome (SS) and systemic lupus erythematosus (SLE), where patientsoften have autoantibodies against different epitopes on TRIM21. READ MORE

  7. 10. Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells

    Author : Jian Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is an important contributor to the development of these tumors. READ MORE