Search for dissertations about: "lineage commitment"

Showing result 1 - 5 of 42 swedish dissertations containing the words lineage commitment.

  1. 1. Lineage commitment to a T

    University dissertation from Lund Stem Cell Center

    Author : Sidinh Luc; Lunds universitet.; Lund University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cell; hematopoiesis; lineage commitment; lymphoid-primed multipotent progenitor;

    Abstract : Popular Abstract in Swedish Kroppens immunförsvar består av röda och vita blodceller som alla härstammar från blodbildande stamceller i benmärgen. Stamcellerna har den unika egenskapen att kunna producera alla typer av blodceller och upprätthålla produktionen hela livet ut. READ MORE

  2. 2. Cellular pathways and molecular regulation of hematopoietic stem cells

    University dissertation from Hematopoietic Stem Cell Laboratory

    Author : Kristina Anderson; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-catenin.; lineage commitment; hematopoietic stem cells; lineage priming; Wnt signaling pathway; biphenotypic cells; PAX5;

    Abstract : Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentiate into all hematopoietic cell lineages. Residing in the bone marrow (BM), adult HSCs are organized in a hierarchy of cells that differ in their self-renewal and proliferative capacity. READ MORE

  3. 3. Maintenance and Commitment of Hematopoietic Progenitors: Role of flt3, c-kit and c-mpl

    University dissertation from Hematopoietic Stem Cell Laboratory

    Author : Ole Johan Borge; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KL; hematopoiesis; FL; cytokines; B-cells; commitment; flt3; differentiation; Haematology; IL-7; c-kit; progenitors; Hematologi; stem cells; thrombopoietin; viability; extracellular fluids; extracellulära vätskor;

    Abstract : The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). READ MORE

  4. 4. The Road to Maturity - Lineage Commitment in early Hematopoiesis

    University dissertation from Lund Stem Cell Center

    Author : Charlotta Böiers; Lunds universitet.; Lund University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Popular Abstract in Swedish Benmärgstransplantation är idag en livsavgörande behandling som används vid leukemi, men även andra sjukdomar. Trots att behandlingen funnits sedan 1950-talet medför den fortfarande komplikationer. Den är ibland inte heller tillräckligt effektiv, och nya strategier behöver utvecklas. READ MORE

  5. 5. Molecular mechanisms in lymphoid restriction securing the B lineage fate

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Josefine Åhsberg; Linköpings universitet.; Linköpings universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. READ MORE