Search for dissertations about: "linkage analysis"

Showing result 1 - 5 of 260 swedish dissertations containing the words linkage analysis.

  1. 1. Exploring the Genetics of SLE with Linkage and Association Analysis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Johansson; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik;

    Abstract : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. READ MORE

  2. 2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    University dissertation from Centre for Mathematical Sciences, Lund University

    Author : Lars Ängquist; Lund University.; Lunds universitet.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

  3. 3. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

    University dissertation from Göteborg : Chalmers University of Technology

    Author : Mikael Knutsson; Göteborgs universitet.; Gothenburg University.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics;

    Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE

  4. 4. On Descriptive and Predictive Models for Serial Crime Analysis

    University dissertation from Karlskrona : Blekinge Institute of Technology

    Author : Anton Borg; Blekinge Tekniska Högskola.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Machine learning; Linkage; Serial crime analysis; Decision support system;

    Abstract : Law enforcement agencies regularly collect crime scene information. There exists, however, no detailed, systematic procedure for this. The data collected is affected by the experience or current condition of law enforcement officers. Consequently, the data collected might differ vastly between crime scenes. READ MORE

  5. 5. Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis

    University dissertation from Karlskrona : Blekinge Institute of Technology

    Author : Svetlana Adamovic; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac Disease; genome-wide scan; linkage; association; GWAS; complex disease; autoimmune; 5q31-33; HLA; IL2 IL21;

    Abstract : Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). READ MORE