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Showing result 1 - 5 of 295 swedish dissertations matching the above criteria.
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1. Exploring the Genetics of SLE with Linkage and Association Analysis
Abstract : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. READ MORE
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2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications
Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE
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3. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis
Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE
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4. On Descriptive and Predictive Models for Serial Crime Analysis
Abstract : Law enforcement agencies regularly collect crime scene information. There exists, however, no detailed, systematic procedure for this. The data collected is affected by the experience or current condition of law enforcement officers. Consequently, the data collected might differ vastly between crime scenes. READ MORE
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5. Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
Abstract : Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). READ MORE