Search for dissertations about: "linkage analysis"
Showing result 21 - 25 of 294 swedish dissertations containing the words linkage analysis.
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21. Topics in Human Gene Mapping
Abstract : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. READ MORE
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22. Genetic characterization of malignant melanoma and breast cancer
Abstract : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. READ MORE
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23. Diagnostic Evaluation of Schizophrenia for Genetic Studies
Abstract : Schizophrenia is one of the most severe mental disorders. Heredity is accepted as a major causative factor. To find molecular mechanisms behind schizophrenia, patient materials with reliable and valid diagnoses must be identified. READ MORE
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24. Genetic studies of stroke in Northern Sweden
Abstract : Stroke is a common disorder of later life with a complex etiology, including both environmental and genetic risk factors. The inherited predisposition is challenging to study due to the complexity of the stroke phenotype. READ MORE
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25. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE
Abstract : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. READ MORE