Search for dissertations about: "lipid droplets"

Showing result 21 - 25 of 38 swedish dissertations containing the words lipid droplets.

  2. 21. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Author : Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Abstract : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. READ MORE

  4. 22. Hormone-Sensitive Lipase, new roles for an old enzyme

    Author : Ola Hansson; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Vitamin A; Inflammation; Medicine human and vertebrates ; Medicin människa och djur ; Metabolism; Hormone-Sensitive Lipase; Proteomics; Obesity; White adipose tissue; Skeletal muscle;

    Abstract : Hormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. READ MORE

  5. 23. Thylakoid Membranes and Pancreatic Lipase/Colipase

    Author : Sinan Cem Emek; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CCK; Thylakoid Membranes; Colipse; Lipase;

    Abstract : Obesity is a major health problem in the world that increases the occurrence of type-2 diabetes and cardiovascular disease. The reason for obesity is a dysfunction in the regulation of energy balance. It has been shown that dietary fat induces satiety as long as this nutrient stays in the intestine. READ MORE

  6. 24. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure

    Author : Andrea Treyer; Per Artursson; Gert Fricker; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular drug bioavailability; unbound drug concentration; drug disposition; ADME; drug transport; drug metabolism membrane partitioning; phospholipid; drug-drug interaction; antisense oligonucleotide; cell-penetrating peptide; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. READ MORE

  7. 25. Metabolic Significance of Fatty Acid Elongation

    Author : Damir Zadravec; Anders Jacobsson; Douglas Tocher; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; fysiologi; Physiology;

    Abstract : Very long-chain fatty acids (VLCFAs), including polyunsaturated fatty acids (PUFAs), are essential lipids whose functional diversity is made possible by variation in their chain length and degree of unsaturation. Fatty acids can either be derived directly from the diet or they can be synthesized de novo through lipogenesis, up to 16 carbons in length by fatty acid synthase. READ MORE