Search for dissertations about: "lipid-based formulation"
Showing result 1 - 5 of 10 swedish dissertations containing the words lipid-based formulation.
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1. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs
Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE
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2. 3D printing of lipid-based formulations into personalized solid oral dosage forms
Abstract : The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all. This is problematic, especially for patient populations with high patient-to-patient variability, as in pediatrics. READ MORE
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3. Predicting oral performance of lipid-based formulations using in vitro methods
Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE
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4. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System
Abstract : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. READ MORE
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5. Studies on intrinsic and extrinsic sources of variability in pharmacokinetics and pharmacodynamics
Abstract : Variability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. READ MORE
