Advanced search

Found 3 swedish dissertations matching the above criteria.

  2. 1. The metabolic syndrome : studies on thrifty genes

    Author : Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

    Abstract : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. READ MORE

  4. 2. Caveolae associated proteins and how they effect caveolae dynamics

    Author : Björn Morén; Richard Lundmark; Volker Haucke; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Caveolae; caveolin; EHD2; cavin; microdomain; microscopy; TIRF; AFM; medicinsk biokemi; Medical Biochemistry;

    Abstract : Caveolae are a type of invaginated membrane domain that has been shown to be involved in several disease states, including lipodystrophy, muscular dystrophies and cancer. Several of these diseases are caused by the lack of caveolae or caveolae-related signaling deficiencies in the tissues in which the caveolar domain are abundant such as lung, adipose, muscle and their related endothelial cells. READ MORE

  5. 3. Metalloproteinases in development and disease

    Author : Zhongjun Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Metalloproteinases are Zn-dependent proteases composed of five superfamilies. One important subfamily is the matrix metalloproteinases (MMPs) that process various components of the extracellular matrix (ECM) and non-ECM proteins. READ MORE