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Showing result 1 - 5 of 105 swedish dissertations matching the above criteria.

  2. 1. Perinatal Energy Substrate Metabolism : Glucose Production and Lipolysis in Pregnant Women and Newborn Infants with Particular Reference to Intrauterine Growth Restriction (IUGR)

    Author : Barbro Diderholm; Jan Gustafsson; Uwe Ewald; Olle Söder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; Lipolysis; Glucose; Newborn infant; Pregnant women; IUGR; Insulin; Stable isotopes; Pediatrik; Paediatric medicine; Pediatrisk medicin;

    Abstract : Glucose is the most important fetal nutrient and the production of this substrate increases in the pregnant woman. In the last trimester the increased insulin resistance directs energy substrates to the fetus. Fetal growth is sometimes disturbed, often without an obvious explanation. READ MORE

  4. 2. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes

    Author : Magdalena Lundgren; Jan Eriksson; Jonas Burén; Eva Degerman; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipose tissue; cAMP; glucocorticoids; glucose; insulin; insulin resistance; lipolysis; subcutaneous fat; type 2 diabetes; visceral fat; Medicine; Medicin;

    Abstract : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. READ MORE

  5. 3. Regulation of glycerol efflux in adipocytes. Structural and functional studies of the glycerol channel aquaporin 7

    Author : Sofia de Mare; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycerol : metabolism; Lipolysis; X-ray Crystallography; Perilipin 1; Aquaglyceroporin; Aquaporin 7; Adipocytes metabolism; Glycerol : metabolism; adipocyte metabolism; X-ray crystallography; Aquaglyceroporin; Aquaporin 7; Perilipin 1; Lipolysis;

    Abstract : Glycerol levels in adipocytes depend on the lipolysis, the hydrolysis of triglycerides into glycerol and free fatty acids, and the efflux of glycerol across the plasma membrane through glycerol channels. The aims of this work were to investigate how glycerol levels are regulated on a molecular level by PLIN1, a major lipid droplet-associated protein and a key regulator of the lipolysis by scaffolding for lipolytic proteins on the lipid droplet. READ MORE

  6. 4. Being Born Large for Gestational Age : Metabolic and Epidemiological Studies

    Author : Fredrik Ahlsson; Jan Gustafsson; Uwe Ewald; Torsten Tuvemo; Olle Hernell; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; large for gestational; glucose production; lipolysis; insulin resistance; intergenerational; gestational diabetes mellitus; stable isotopes; pregnant women; newborn infant; Palliative medicine; Palliativ medicin;

    Abstract : Obesity is a major health problem in the Western world. Mean birth weight has increased during the last 25 years. One explanation is that the proportion of large for gestational age (LGA) infants has increased. Such infants risk developing obesity, cardiovascular disease and diabetes later in life. READ MORE

  7. 5. Predicting oral performance of lipid-based formulations using in vitro methods

    Author : Oliver Hedge; Christel Bergström; Frédéric Carriere; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation s ; SEDDS; artificial membrane s ; cell monolayer s ; oral drug delivery; lipolysis; permeation; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE