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Showing result 1 - 5 of 51 swedish dissertations matching the above criteria.

  2. 1. Lipoprotein lipase : mechanism for adaptation of activity to the nutritional state

    Author : Gengshu Wu; Thomas Olivecrona; Gunilla Olivecrona; Peter Nisson-Ehle; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; adipose tissue; heparin; extracellular; nutrition; turnover; actinomycin; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Lipoprotein lipase (LPL) is an enzyme to hydrolyze triglycerides in lipoproteins and thereby make the fatty acids available for cellular metabolic reactions. Short-term fasting down-regulates LPL activity in adipose tissue. This regulation is through post-translational mechanism. READ MORE

  4. 2. Regulation of Lipoprotein Lipase Activity : an In-vitro Study of a Complex and Dynamic System

    Author : Oleg Kovrov; Gunilla Olivecrona; Aivar Lookene; Mikael Larsson; Geesje Dallinga-Thie; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglyceride Metabolism; Lipoprotein lipase; Angiopoietin-Like Proteins; Apolipoproteins; Isothermal titration calorimetry; Biochemistry; biokemi; molekylärbiologi; Molecular Biology;

    Abstract : The progress of human society outpaces our biological evolution, and this brings unexpected health problems. The industrial revolution brought up dramatic changes in nutrition and lifestyle – we are increasingly shifting towards a nutrient-rich Western-patterned diet and to a sedentary lifestyle. READ MORE

  5. 3. Lipoprotein lipase-unstable on purpose?

    Author : Liyan Zhang; Gunilla Olivecrona; Cecilia Holm; Umeå universitet; []
    Keywords : Biochemistry; Lipoprotein lipase; Apolipoprotein CII; dimerization; monomerization; Molecular chaperones; Biokemi;

    Abstract : Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. It is a non-covalent, homodimeric and N-glycosylated protein, which is regulated in a tissue-specific manner and is dependent on an activator protein, apolipoprotein CII. Dissociation of active LPL dimers to monomers leads to loss of activity. READ MORE

  6. 4. Lipoprotein lipase and salt resistant lipase : purification, characterization and studies on the activation of lipases from bovine milk and human post-heparin plasma

    Author : Ann-Margret Östlund-Lindqvist; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  7. 5. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Author : Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. READ MORE