Search for dissertations about: "liposomes drug delivery"

Showing result 1 - 5 of 19 swedish dissertations containing the words liposomes drug delivery.

  1. 1. Liposomes for Drug Delivery : from Physico-chemical Studies to Applications

    Author : Nill Bergstrand; Katarina Edwards; Felix M Goni; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. READ MORE

  2. 2. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

    Author : Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. READ MORE

  3. 3. Development of a targeted Drug Delivery System for treatment of Pancreatic Ductal Adenocarcinom

    Author : Carlos Urey; Lund Kirurgi; []
    Keywords : Drug Delivery Systems; Liposomes; Pancreatic cancer;

    Abstract : Pancreatic cancer is the fourth leading cause of cancer-related death with a 5-year survival of less than 6%. The only potential cure for pancreatic cancer is by surgical removal of the tumor. However, most patients present with an advanced and metastasized disease at the time of diagnosis, leaving only around 15% of patients eligible for surgery. READ MORE

  4. 4. Membrane Interactions of Arginine-Rich Peptides for the Intracellular Delivery of Gene-Targeted Drugs

    Author : Per Thoren; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cellular uptake; translocation; protein transduction; circular dichroism; drug delivery; liposomes; resonance energy transfer; PNA; antigene; antisense;

    Abstract : A major obstacle for the therapeutic use of e.g. oligonucleotides is their inherently poor cellular uptake. A recently discovered class of peptides, denoted cell-penetrating peptides, has been shown to traverse cell membranes, even when conjugated to oligonucleotides or even full-length proteins. READ MORE

  5. 5. Synthesis and Applications of Dynamic Multivalent Nanostructures

    Author : Kitjanit Neranon; Olof Ramström; Aldrik Velders; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; multivalent nanostructures; self-assembly; metal-ligand exchange; dynamic covalent chemistry; bipyridine derivatives; dendrimers; liposomes; drug delivery; antimicrobial materials; fluorescent probe; plasmonic chemistry; gold surface functionalization; Kemi; Chemistry;

    Abstract : This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. READ MORE