Search for dissertations about: "lipotoxicity"

Showing result 1 - 5 of 21 swedish dissertations containing the word lipotoxicity.

  2. 1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Author : Siri Malmgren; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Abstract : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. READ MORE

  4. 2. Hormone-Sensitive Lipase and the Pancreatic Beta-Cell

    Author : Håkan Lindvall; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; cytogenetics; Genetik; Genetics; cloning; gene expression; lipase; insulin secretion; diabetes; lipotoxicity;

    Abstract : Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization. It is acutely regulated by extracellular signals via reversible phosphorylation. In the recent past, the focus of type 2 diabetes research has moved towards the lipid component. READ MORE

  5. 3. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system

    Author : Jörgen Borg; Molekylär endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biology; Biologi; lipotoxicity; beta-cell; perilipin; amino-terminal anchor; Baculovirus; surface display;

    Abstract : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. READ MORE

  6. 4. Effects of Free Fatty Acids on Insulin and Glucagon Secretion : – with special emphasis on the role of Free fatty acid receptor 1

    Author : Hjalti Kristinsson; Peter Professor; Birgitte Holst; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FFAR1; GPR40; palmitate; lipotoxicity; islets of Langerhans; type 2 diabetes; obesity; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Prevalence of type 2 diabetes mellitus (T2DM) is still rising and even so in the juvenile population. Obesity is highly associated with increased risk for developing T2DM. READ MORE

  7. 5. Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2

    Author : Henrik Palmgren; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane lipids; Membrane fluidity; Membrane homeostasis; Dietary lipids; Phospholipids; Genetics; Lipotoxicity; Lipidomics; ADIPOR2; TLCD1; TLCD2;

    Abstract : Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which proteins and carbohydrates are anchored and exert their function. READ MORE