Search for dissertations about: "liquid chromatography-mass spectrometry"

Showing result 6 - 10 of 90 swedish dissertations containing the words liquid chromatography-mass spectrometry.

2. 6. Liquid chromatography-mass spectrometry in the analysis of radiolabelled compounds for positron emission tomography

   Author : Benita Hyllbrant Forngren; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; Analytical Chemistry; analytisk kemi;

   Abstract : Methods for liquid chromatography-mass spectrometry (LC/MS) with electrospray ionization (ESI) have been developed for the determination of specific radioactivity and for metabolic studies of radiolabelled compounds used in positron emission tomography (PET). These compounds often provide an analytical challenge mainly due to their low concentrations in complex sample matrices. READ MORE

4. 7. Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone

   Author : Ingela Sundström; Per Andrén; Douglas Westerlund; Monika Johansson; Uppsala universitet; []
   Keywords : Analytical chemistry; LC-MS MS; accurate mass measurement; drug metabolites; microdialysate; brain; fluorinated stationary phase; phenylboronic acid; retention mechanism; Analytisk kemi;

   Abstract : Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. READ MORE

5. 8. Hydroxamate Siderophores and Low Molecular Mass Organic Acids in Terrestrial and Aquatic Environments Determined by Liquid Chromatography Mass Spectrometry

   Author : Sofia Essén; Ulla Lundström; Dan Bylund; Mittuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi;

   Abstract : Siderophores are low molecular mass organic compounds with high iron(III) stability constants. They are produced by many microorganisms, often in combination with low molecular mass organic acids (LMMOAs). Both siderophores and LMMOAs accelerate mineral weathering, thereby enhancing mineral nutrient availability. READ MORE

6. 9. On the investigation of chemical parameters reflecting microbial activity linked to nutrient availability in forest soil

   Author : Madelen Olofsson; Dan Bylund; Bengt-Gunnar Jonsson; Bjarne W. Strobel; Mittuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Boreal forest; electrospray ionization; fungal biomass; hydrophilic interaction chromatography; hydroxamate siderophores; liquid chromatography-mass spectrometry; mineral amendment; aromatic acids; podzol soil;

   Abstract : As agrarian society developed, the most fertile soils able to sustain the nutritional requirements needed for high crop yield were assigned to farming, while the more penurious soils were left to uphold the forest ecosystems. Some temperate forests are developed on acidic soils considered to be nutrient poor, as much of the inorganic nutrients are entrapped in poorly weatherable soil minerals and not easily accessed by plant roots. READ MORE

7. 10. Arachidonic acid metabolism in corneal epithelial cells : Identification of lipoxygenase isoforms

   Author : Maria Liminga; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Cornea; cDNA cloning; lipoxygenase; liquid chromatography-mass spectrometry; organ culture; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Abstract : The metabolism of arachidonic acid in the human cornea was investigated and compared with the metabolism in cattle and primates. All three species showed significant arachidonic acid metabolism inthe epithelium, whereas the activity in the stroma and the endothelium was low or undetectable. READ MORE