Search for dissertations about: "liver development"

Showing result 1 - 5 of 412 swedish dissertations containing the words liver development.

  2. 1. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease

    Author : Ewa Wandzioch; Leif Carlsson; Stephen A Duncan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; liver fibrosis; liver development; Lhx2; hematopoietic stem cells; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. READ MORE

  4. 2. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

    Author : Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Abstract : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. READ MORE

  5. 3. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

    Author : Magnus Ölander; Per Artursson; Pär Matsson; Edward L. LeCluyse; Volker Lauschke; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. READ MORE

  6. 4. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

    Author : Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. READ MORE

  7. 5. Spatiotemporal Profiling of Human Development Using Multiplexed Imaging

    Author : Sanem Sariyar; Emma Käller Lundberg; Burcu Ayoglu; Gunilla Westergren-Thorsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; human development; organ development; spatial proteomics; single-cell proteomics; proliferation; immune system; mänsklig utveckling; organutveckling; spatial proteomik; single-cell proteomik; proliferation; immunsystem; Biotechnology; Bioteknologi;

    Abstract : Human development is complex and intricate, where the positions of cells, expression of key markers, and cell-cell interactions contribute to the development of various organs from different germ layers and the establishment of the body axis. Therefore, understanding human development within spatial and temporal aspects is crucial. READ MORE