Search for dissertations about: "loci"

Showing result 1 - 5 of 533 swedish dissertations containing the word loci.

2. 1. Genetic analysis of murine malaria

   Author : Susana Campino; Dan Holmberg; Nils Lycke; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Malaria; genetic analysis; Plasmodium; wild derived inbred strains; loci; cerebral malaria; hyperparasitaemia.; Genetik; Clinical genetics; Klinisk genetik; genetik; Genetics;

   Abstract : Malaria, an infectious disease caused by Plasmodium parasites, is one of the major world-scale health problems. Despite the efforts aimed at finding an effective way to control the disease, the success has been thwarted by the emergence of parasite drug resistance and mosquito resistance to insecticides. READ MORE

4. 2. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation

   Author : Xia Shen; Örjan Carlborg; Lars Rönnegård; William Hill; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; statistical genetics; quantitative trait loci; genome-wide association study; genomic selection; genetic variance; hierarchical generalized linear model; linear mixed model; random effect; heteroscedastic effects model; variance-controlling genes; Complex Systems – Microdata Analysis;

   Abstract : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. READ MORE

5. 3. Studies of risk loci in multiple sclerosis

   Author : Magdalena Lindén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system, is one of the most common causes of neurological disability among young adults. While the etiology is unknown, an increasing number of environmental and genetic risk factors is being identified. READ MORE

6. 4. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

   Author : Anna-Karin B. Lindqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. READ MORE

7. 5. Genetic Loci Contributing to Spontaneous Autoimmune Diabetes

   Author : Jessica Fuller; Celiaki och diabetes; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lymphopenia; BB Rat; Type 1 Diabetes; T Cell Receptor; Autoimmunity; Gimap;

   Abstract : Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for external manipulation. READ MORE