Search for dissertations about: "long-term humoral immunity"

Showing result 1 - 5 of 12 swedish dissertations containing the words long-term humoral immunity.

2. 1. Varicella immunity and vaccination

   Author : Anita Svahn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Varicella-zoster virus (VZV) is an air-borne, extremely contagious herpesvirus. It causes chickenpox, which usually is a benign illness in childhood. Adults, pregnant women and immunocompromised patients often get a severe disease with complications. After infection the virus stays latent in sensory ganglia. READ MORE

4. 2. Herpesvirus Infection and Immunity in Neurocognitive Disorders

   Author : Gabriel Westman; Britt-Marie Eriksson; Martin Ingelsson; Olle Korsgren; Jan Ernerudh; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Herpes simplex encephalitis; Herpesvirus; Cytomegalovirus; CMV; HSV-1; HHV-6; CD8 T-cells; Cellular immunity; Immunosenescence; Autoimmunity; NMDA receptor; Medicinsk vetenskap; Medical Science;

   Abstract : Herpesviruses have co-speciated with several vertebrate and invertebrate animals throughout the history of evolution. In the immunocompetent human host, primary infection is usually benign, whereafter the virus is brought into life-long latency. READ MORE

5. 3. Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection

   Author : Kehmia Titanji; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1 infection; HIV-2 infection; B cells; primary HIV-1 infection; immune activation; hypergammaglobulinemia; long-term humoral immunity; antiretroviral therapy;

   Abstract : B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against the virus, but may be the root cause of B cell dysfunctions. READ MORE

6. 4. Humoral immunity during primate lentivirus infection : evaluation of B cell apoptosis and engineering of virus specific antibodies

   Author : Astrid Samuelsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The focus of this project was to evaluate the contribution of the humoral immunity in controlling infection with primate lentiviruses - an area which has implications both for vaccine design as well as for understanding of the pathogenesis of the disease. The first goal was to generate efficient neutralizing reagents which could be used for passive immunotherapy trials, preferably in the macaque system, and to investigate if peptide immunogens could elicit such antibodies. READ MORE

7. 5. Studies on Potency and breadth of HIV-1, HIV-2 and SIV neutralizing antibody responses

   Author : Gülsen Özkaya Sahin; Avdelningen för medicinsk mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; SIV; envelope; neutralizing antibody; breadth; potency; IgG; IgA; complement; antibody-dependent complement-mediated inactivation; virus evolution; diversity; divergence;

   Abstract : Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimulation, the preservation of CD4+ T and B cells, the conformation of the HIV-1 envelope glycoprotein complex (Env), and the evolution of Env during infection. READ MORE