Search for dissertations about: "loop-helix proteins"

Showing result 11 - 15 of 30 swedish dissertations containing the words loop-helix proteins.

  2. 11. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins

    Author : Cecilia Winander; Lars Baltzer; Stefan Sjöberg; Jörgen Carlsson; Vladimir Tolmachev; Thomas Schrader; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carborane; doxorubicin; 125I; molecular recognition; four-helix bundle; polypeptide conjugate; affinity; chitinase; acetylcholine esterase; Organisk kemi;

    Abstract : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. READ MORE

  4. 12. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins

    Author : Julianna M V Kele-Olovsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. READ MORE

  5. 13. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

    Author : Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. READ MORE

  6. 14. bHLH transcription factors in differentiating neuroblastoma cells

    Author : Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE

  7. 15. Nuclear pore membrane glycoprotein 210 as a new marker for epithelial cells

    Author : Magnus Olsson; Neus Visa; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Nuclear pore complex; gp210; Nulp1; epithelial cells; kidney development; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial cell polarisation is a prerequisite for the branching morphogenesis in several organs. Differential screening techniques were used to identify genes, which are upregulated during induction of epithelium in early kidney development. READ MORE