Search for dissertations about: "losartan"

Showing result 1 - 5 of 19 swedish dissertations containing the word losartan.

  2. 1. Effects of Dehydration and Blockade of the Renin-Angiotensin System in the One-humped Camel (Camelus dromedarius)

    Author : Mahmoud Al Haj; Fred Nyberg; Santi Spampinato; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood; biochemical analysis; catecholamine; colorimetric assay; cortisol; dehydration; dromedary camel; glutathione; hematological analysis; HPLC; insulin- like growth factor-1; losartan; plasma; receptors; radioimmunoassay; serum; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : The one-humped or the dromedarian camel is a pseudo-ruminant mammal, well adapted to the hot and dry climates of the desert. Its ability to withstand torrid heat and extreme desiccation is of paramount importance to its survival. READ MORE

  4. 2. Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology

    Author : Umit Yasar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CYP2C9 polymorphism; phenotyping; genotyping; diclofenac; losartan;

    Abstract : Cytochrome P450 2C9 (CYP2C9) is one of the most important drug metabolizing enzymes in human liver. It catalyses the metabolism of a wide range of different drugs such as S-warfarin, acenocoumarol, losartan, irbesartan, phenytoin, sulphamethoxazole, tolbutamide, glipizide and numerous non-steroidal antiinflammatory drugs. READ MORE

  5. 3. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

    Author : Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

    Abstract : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. READ MORE

  6. 4. Dopamine coordinates the effect of natriuretic and antinatriuretic factors

    Author : Susanne Crambert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Living organisms are dependent on a precise regulation of water and sodium. The stability of the internal environment is maintained through a series of feedback mechanisms, in response to changes within the organism as well as to changes in the external environment. READ MORE

  7. 5. The Role of Angiotensin II in Experimental Acute Kidney Injury and Cardiorenal Failure

    Author : Sofia Jönsson; Michael Hultström; Helle Prætorius Øhrwald; Uppsala universitet; []
    Keywords : Heart failure; Acute kidney injury; Angiotensin II; Fluid balance; Cardiac function; Renal function;

    Abstract : Blood pressure and fluid regulation are kept constant through the interaction between heart and kidneys. When the systemic blood pressure decreases, the levels of the hormone Angiotensin II increase, leading to vasoconstriction and therefore increased blood pressure. READ MORE