Search for dissertations about: "low MBL"

Showing result 1 - 5 of 13 swedish dissertations containing the words low MBL.

  1. 1. The PD-1 pathway and the complement system in systemic lupus erythematosus

    Author : Helga Kristjánsdóttir; Marta E Alarcón-Riquelme; Kristján Steinsson; Tom W J Huizinga; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; SLE; autoimmune diseases; PD-1; C4AQ0; low MBL; multicase family; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Abstract : Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. READ MORE

  2. 2. Recognition molecules of the complement system: C1q and mannan-binding lectin in autoimmunity and immune defence

    Author : Ulla Mårtensson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serologi; Immunologi; Immunology; serology; autoantibodies; collectins; complement; autoimmunity; Infections; Infektioner;

    Abstract : The C1 subcomponent C1q and the mannan-binding lectin (MBL) are recognition proteins of the complement system, and have similar structure. C1q binds to IgG and IgM and activates the classical pathway. MBL binds to carbohydrate structures and activates the lectin pathway. READ MORE

  3. 3. Myocardial infarction and diabetes mellitus : Studies on glucose lowering therapies and novel risk markers based on observations from the DIGAMI 2 trial

    Author : Linda Garcia Mellbin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Background Patients with myocardial infarction (MI) and type 2 diabetes (T2DM) and have a poor prognosis. Hyperglycemia is an independent risk predictor. The best tools for glucose control are debated. Important is identification of biomarkers to gain further pathophysiological insights and new therapeutic possibilities. READ MORE

  4. 4. Severe sepsis : epidemiology and sex-related differences in inflammatory markers

    Author : Sofie Jacobson; Ola Winsö; Stefan Söderberg; Peter Larsson; Else Tönnesen; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Severe sepsis; Leptin; Adiponectin; Mannose-binding lectin; Sex; Anaesthesiology; anestesiologi;

    Abstract : Background.  Sepsis is a syndrome associated with high mortality rates, substantial morbidity and high costs of care. The incidents of sepsis is reported to be high and controversy exists whether gender affect severity or outcome. READ MORE

  5. 5. Polymorphism in pattern recognition receptor genes in pigs

    Author : Ingrid-Maria Bergman; Inger Edfors; Kristina Nilsson Ekdahl; Kjell Edman; Dag Inge Våge; Linnéuniversitetet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : The mammalian immune defense consists of two systems, which are interconnected and co-operate to provide host defense. The innate immune system is always active and detects and responds to non-self without delay. The adaptive immune system has a lag phase, but is more specific and has got a memory. READ MORE