Search for dissertations about: "low affinity interactions"

Showing result 16 - 20 of 85 swedish dissertations containing the words low affinity interactions.

  2. 16. Method development for affinity capillary electrophoresis of ß2-glycoprotein I and biological ligands

    Author : Maria E. Bohlin; Lars G Blomberg; Niels H H Heegaard; Jan Leo Reubsaet; Karlstads universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Capillary Electrophoresis; β2-glycoprotein I; acidic pretreatment; pH hysteresis effect; Affinity Capillary Electrophoresis; Kemi; Chemistry;

    Abstract : The final goal of this study is to establish a microscale analysis method that allows solution phase characterization of interactions between β2-glycoprotein I (β2gpI) and some of its ligands. Human β2gpI is a phospholipid- and heparin-binding plasma glycoprotein. READ MORE

  4. 17. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

    Author : Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

    Abstract : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. READ MORE

  5. 18. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands

    Author : Kristoffer Peterson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectin; Structure-based design; Thiodigalactoside; Huisgen 1; 3-dipolar cycloaddition; Protein-ligand binding interactions;

    Abstract : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. READ MORE

  6. 19. Exploration of analytical methods to study motif-mediated host-virus protein-protein interactions

    Author : Eszter Kassa; Ylva Ivarsson; Gilles Travé; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein-protein interaction; short linear motif; affinity purification-mass spectrometry; virus; SARS-CoV-2; TBEV; Analytical Chemistry; Analytisk kemi;

    Abstract : Proteins are responsible for countless processes in living creatures, but most often they do not perform these tasks alone. Rather, they engage in interactions with other proteins, creating whole protein-protein interaction (PPI) networks. READ MORE

  7. 20. Thermodynamics of Peptide Nucleic Acid Interactions with DNA

    Author : Tommi Ratilainen; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; thermodynamics; enthalpy-entropy compensation; ionic strength; nucleic acids; fluorescence energy transfer; PNA; calorimetry; sequence-specific binding;

    Abstract : Peptide Nucleic Acid (PNA) is a DNA mimic with the natural nucleobases attached to a charge-neutral pseudopeptide backbone. It has remarkably strong and sequence-specific binding affinity to natural nucleic acids (DNA and RNA), mainly attributed to the lack of charge in the PNA backbone. READ MORE