Search for dissertations about: "lumefantrine"

Showing result 11 - 15 of 18 swedish dissertations containing the word lumefantrine.

  2. 11. Modelling and Simulation to Improve Antimalarial Therapy

    Author : Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE

  4. 12. Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum

    Author : Pedro Ferreira; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum;

    Abstract : Malaria, caused by the Plasmodium falciparum parasite, remains a leading cause of death among children in Africa. To improve treatment efficacy and delay development and spread of antimalarial drug resistance artemisinin artemisinin-based combination therapy (ACT) is now globally recommended as first-line treatment of uncomplicated P. READ MORE

  5. 13. Aspects of molecular markers in drug resistant malaria

    Author : Irina Tatiana Jovel Quiñonez Dalmau; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : BACKGROUND: There were an estimated 207 million cases of malaria in 2012 of which 91% were due to Plasmodium falciparum. Antimalarial drug resistance constitutes a major problem in the efforts to control malaria. READ MORE

  6. 14. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Author : Sofia Friberg Hietala; Göteborgs universitet; []
    Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

  7. 15. Efficacy of artemisinin based combination therapy and effectiveness of rapid diagnostic test for management of patients with plasmodium falciparum malaria in Zanzibar

    Author : Mwinyi I Msellem; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum malaria; artemisinin-based combination therapies ACTs ; efficacy; rapid diagnostic test RDT ; Zanzibar;

    Abstract : Background: Due to rapid spread of antimalarial drug resistance to Plasmodium falciparum malaria many African countries have recently changed their first-line treatment policy to artemisinin-based combination therapy (ACT). Zanzibar was one of the first regions in Africa to implement ACT free of charge to all age groups through public health facilities in 2003. READ MORE