Search for dissertations about: "lumefantrine"

Showing result 6 - 10 of 18 swedish dissertations containing the word lumefantrine.

  2. 6. Effect of local food on lumefantrine bioavailability and population pharmacokinetics in Ugandan children with malaria

    Author : Norah Mwebaza; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background. Artemether-lumefantrine (AL) is widely adopted as first-line treatment for uncomplicated malaria. Lumefantrine (LUM), the long acting partner drug is critical for cure by eliminating malaria parasites left after artemether exposure. READ MORE

  4. 7. Improved malaria case management in under-fives in the era of Artemisinin-based combination therapy in Tanzania

    Author : Billy Ephraim Ngasala; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria microscopy; case management; efficacy; effectiveness; artemether-lumefantrine; retreatment; lumefantrine concentrations; randomized trial; Tanzania;

    Abstract : Early parasite-based diagnosis of malaria prior to treatment is critical for rational drug use, optimal outcome of febrile illness, patient adherence, prevention of parasite drug resistance, and reduced costs of health services. However, most primary health care (PHC) facilities in sub-Saharan Africa have no laboratory support and malaria diagnosis is based on clinical symptoms and signs, which are nonspecific. READ MORE

  5. 8. Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro

    Author : Shelton Tendai Mariga; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria; synergy; combination therapy; Plasmodium falciparum; amodiaquine; lumefantrine; resistance; pharmacodynamics;

    Abstract : Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed. READ MORE

  6. 9. Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau

    Author : Johan Ursing; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of resistance, chloroquine is no longer efficacious in most of the world. The first line option for treatment of P. READ MORE

  7. 10. Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs

    Author : Sabina Dahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Half of the world's population live at risk for malaria and nearly one million people die from the disease every year. The malaria burden is greatest in children and pregnant women in sub-Saharan Africa. READ MORE