Search for dissertations about: "lungs"

Showing result 1 - 5 of 336 swedish dissertations containing the word lungs.

  1. 1. Drug absorption in the lungs : studies in the isolated perfused rat lung model combined with physiologically based biopharmaceutics modelling

    Author : Johanna Eriksson; Hans Lennernäs; Erik Sjögren; Helena Thörn; Ben Forbes; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug absorption; physiologically based biopharmaceutics modeling; pulmonary drug delivery; Biofarmaci; Biopharmaceutics;

    Abstract : Pulmonary delivery of drugs is the preferred route of administration for treatment of local lung diseases like asthma and chronic obstructive pulmonary disease. Recently, there has also been increased interest in systemic delivery of drugs via the lungs to avoid problems with low and/or variable gastrointestinal absorption, and as a needle-free alternative for drugs that cannot be ingested. READ MORE

  2. 2. Interleukin-17 in models of neutrophilic lung disease

    Author : Stefan Ivanov; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Interleukin-17; Interleukin-23; Matrix metalloproteinase-9; neutrophils; macrophages; CD4 cells; innate response; lungs;

    Abstract : Several acute or chronic lung disorders like adult respiratory distress syndrome, acute severe asthma, chronic obstructive pulmonary disease, chronic lung allograft rejection and cystic fibrosis, are associated with signs of an excess innate response in the bronchoalveolar space. Neutrophils may play a pathogenic role in these lung diseases by contributing to non-specific bronchial hyperresponsiveness and bronchial hypersecretion, as well as to epithelial damage and tissue remodelling. READ MORE

  3. 3. Mechanisms of inflammatory lung injury : Studies in isolated perfused rat lungs

    Author : Anders Ljungman; Östergötlands Läns Landsting; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Isolated perfused rat lungs (IPRLs) were used to study mechanisms andmediators of lung injury due to (i) ischemia-reperfusion (IR) and (ii) endotoxin. To investigate the role of polymorphonuclear neutrophils (PMNs) in IR injury, PMNs were added to the perfusate of IPRLs subjected to IR. READ MORE

  4. 4. Recruitment of small size lungs - experimental studies

    Author : Angela Hanson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung recruitment; PEEP titration; VTCO2; Cdyn; computed tomography; cardiac output; atelectasis; lung aeration; driving pressure;

    Abstract : Background: Patients - both children and adults - undergoing anesthesia and mechanical ventilation rapidly develop atelectasis. Even more severe problems occur in patients with acute lung injury/acute respiratory distress syndrome. READ MORE

  5. 5. Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases

    Author : Tina Heyder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases are debilitating conditions representing a major health problem throughout the world. READ MORE