Search for dissertations about: "lupus erythematosus"

Showing result 21 - 25 of 153 swedish dissertations containing the words lupus erythematosus.

2. 21. C-reactive protein (CRP) and anti-CRP autoantibodies in systemic lupus erythematosus : a study on the occurrence and clinical implications of anti-CRP antibodies and CRP-mediated complement activation

   Author : Christopher Sjöwall; Thomas Skogh; Johan Frostegård; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; complement activation; C-reactive protein; cytokines; immune complex; immunoregulation; opsonization; systemic lupus erythematosus; Rheumatology; Reumatologi;

   Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of a wide range of autoantibodies, multiple organ involvement and by local formation or tissue deposition of immune complexes (ICs) in the inflamed organs. In contrast to most systemic inflammatory conditions, and despite raised levels of pro-inflammatory cytokines, SLE flares are rarely reflected by elevated C-reactive protein (CRP), an important acute-phase reactant in man with homologs in vertebrates and several invertebrates. READ MORE

4. 22. Biomarkers and mediators in systemic lupus erythematosus : IFNα versus the CRP response, and evaluation of suPAR and anti-dsDNA antibody assays

   Author : Helena Enocsson; Jonas Wetterö; Thomas Skogh; Christopher Sjöwall; Søren Jacobsen; Linköpings universitet; []
   Keywords : ;

   Abstract : Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease which may affect multiple organ systems. Interferon alpha (IFNα) and autoantibodies that form immune complexes with nuclear antigens (ANA) are hallmarks believed to drive the disease into a vicious circle of inflammation, tissue damage, autoantigen exposure and autoantibody production. READ MORE

5. 23. Studies of atherosclerosis in systemic lupus erythematosus

   Author : Cristina Anania; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The role of inflammation in the development of atherosclerosis is now accepted and a focus of many studies because of its complex mechanisms. The risk of cardiovascular disease (CVD) and atherosclerosis is reported to be increased in systemic lupus erythematosus (SLE), especially in the group of young women. READ MORE

6. 24. Autoantibodies and the Type I Interferon System in the Etiopathogenesis of Systemic Lupus Erythematosus

   Author : Stina Blomberg; Johan Frostegård; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; type I interferon; interferon inducer; dendritic cell; natural interferon-alpha producing cell; immune complex; SSA Ro; dsDNA; BDCA; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

   Abstract : In sera remitted for anti-nuclear antibody (ANA) analysis, the supplement of a sensitive anti-SSA/Ro ELISA to the conventional ANA screening by immunofluorescence (IF) revealed that one fourth of the individuals with IF-ANA negative, but SSA/Ro ELISA positive sera, had systemic lupus erythematosus (SLE) or cutaneous LE. Consequently, adding a sensitive anti-SSA/Ro ELISA to the ANA screening is valuable for the serological detection of ANA negative SLE/LE patients. READ MORE

7. 25. The Role of Plasmacytoid Dendritic Cells and Natural Killer Cells in Systemic Lupus Erythematosus

   Author : Niklas Hagberg; Lars Rönnblom; Maija-Leena Eloranta; George Tsokos; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; plasmacytoid dendritic cells; natural killer cells; type I interferon; immune complex; SLAM receptors; autoantibodies; CD94 NKG2A; CD94 NKG2C; Medicinsk vetenskap; Medical Science; Immunologi; Immunology;

   Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, which can eventually lead to immune complex (IC)-mediated organ damage. Due to the stimulation of plasmacytoid dendritic cells (pDC) by nucleic acid-containing ICs (DNA- or RNA-IC), patients with SLE have an ongoing interferon (IFN)-α production. READ MORE