Search for dissertations about: "lymphoid maturation"

Showing result 1 - 5 of 25 swedish dissertations containing the words lymphoid maturation.

  2. 1. What’s in a name? : Sub-fractionation of common lymphoid progenitors

    Author : Sasan Zandi; Mikael Sigvardsson; Avinash Bhandoola; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The hematopoietic system is a highly dynamic organ developed in many multi-cellular organisms to provide oxygen, prevent bleeding and to protect against microorganisms. The blood consist of many different specialized cells that all derive from rare hematopoietic stem cells (HSCs) located in the bone marrow in mice and humans. READ MORE

  4. 2. Regulation of dendritic cell differentiation, maturation and activation

    Author : Jin Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immune system efficiently protects the host from exogenous pathogens such as bacteria, virus and parasites and endogenous threats such as damaged cells and tumors. Invasion of pathogens and other threats activate the innate immunity causing secretion of pro-inflammatory cytokines with the subsequent antigen presentation and activation of the adaptive immunity resulting in T and B cell responses. READ MORE

  5. 3. HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation

    Author : Alberto Cagigi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Currently, big efforts in HIV-1 research are devoted to the design of a HIV-1 vaccine. However, no successful vaccine is yet available, also due to the lack of basic knowledge in HIV-1 pathogenesis which is still profound. READ MORE

  6. 4. DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity

    Author : Åsa Holgersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA-PK; lymphoid maturation; lymphocytic leukaemia; radiation sensitivity; drug sensitivity; drug resistance; sensitisation.;

    Abstract : The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes two processes, V(D)J recombination and lg switch recombination, during which DSBs are naturally occurring events. READ MORE

  7. 5. Immunological properties of dendritic cells in HIV-1 infection

    Author : Karin Loré; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dendritic cells; HIV-1; Cytokines; Chemokines; Co-stimulatory molecules; Apoptotic bodies; Lymphoid tissue;

    Abstract : Dendritic cells (DCs) capture antigens for intracellular processing to form MHC-peptide complexes involved in the generation of antigen specific T cell responses. After encountering microbes, DCs migrate from the periphery to the regional lymph nodes. READ MORE