Search for dissertations about: "lymphoma, p53"

Showing result 1 - 5 of 32 swedish dissertations containing the words lymphoma, p53.

  2. 1. Aggressive lymphoma

    Author : Mats Jerkeman; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; BCL6 rearr; 1q21-23; cytogenetics; histopathology; P-glycoprotein; p53; BCL2; Ki-67; immunohistochemistry; proliferation; dose intensity; health-related quality of life; International Prognostic Index; prognostic factors; aggressive lymphoma; chemotherapy; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; cancer; onkologi; Cytologi; cancerology; oncology;

    Abstract : Aggressive lymphoma is a rapidly growing tumour of lymphocyte origin, potentially curable with chemotherapy. In a trial by the Nordic Lymphoma Group, 405 patients with aggressive lymphoma were included, and randomised to receive either the standard chemotherapy regimen, CHOP, or a weekly multidrug regimen, MACOP-B. READ MORE

  4. 2. Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas

    Author : Rose-Marie Amini; Volker Diehl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin lymphoma; advanced stages; relapse; p53; EBV; Rb; cell line; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Abstract : The relationship between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) is not entirely elucidated and a clonal relation may be present more often than previously believed. Mechanisms of tumour progression and resistance to therapy are poorly understood.Between 1974 and 1994 all individuals in Sweden with both HL and NHL were identified. READ MORE

  5. 3. SOX11 in Mantle Cell Lymphoma - Novel Tools for Diagnostic, Prognostic and Functional Investigations

    Author : Lena Nordström; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibodies; DNA methylation; Epigenetics; SOX11; Lymphoma;

    Abstract : The goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. READ MORE

  6. 4. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  7. 5. p53 functional loss by mutation and p53 antagonizing proteins during tumor development

    Author : Qian Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : p53 is the most common target for genetic alterations in human cancers. Inactivation of wild type p53 function by point mutation, deletion or complexing with antagonizing proteins such as MDM2 and DNA tumor viral oncoproteins, is frequently found in human and rodent tumors. READ MORE