Search for dissertations about: "lymphoma 2019"

Showing result 1 - 5 of 11 swedish dissertations containing the words lymphoma 2019.

2. 1. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind

   Author : Zahra Haider; Sofie Degerman; Magnus Hultdin; Göran Roos; Pieter van Vlierberghe; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia; Lymphoma; T-ALL; BCP-ALL; T-LBL; DNA methylation; CIMP; Prognosis; TAL1; HOX.;

   Abstract : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. READ MORE

4. 2. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

   Author : Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

   Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE

5. 3. Harnessing the power of model systems to investigate regulation of Anaplastic Lymphoma Kinase function

   Author : Patricia Mendoza-Garcia; Ruth Palmer; Jan Larsson; Åsa Rasmuson Lestander; Stefan Luschnig; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; RTK; ALK; Drosophila; Danio rerio; ALKALs; signal transduction; transcription factor; visceral mesoderm; iridophores; neural crest; molekylärbiologi; Molecular Biology;

   Abstract : The anaplastic lymphoma kinase (ALK), initially identified as a translocation partner in anaplastic large cell lymphoma (ALCL), has been described in a number of tumors such as neuroblastoma. Neuroblastoma is a neural crest derived malignancy of the sympathetic nervous system. READ MORE

6. 4. Molecular epidemiology approach : nested case-control studies in glioma and lymphoid malignancies

   Author : Florentin Späth; Beatrice S. Melin; Carl Wibom; Ann Sofie Johansson; Ingvar Bergdahl; Ola Landgren; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; B cell lymphoma; multiple myeloma; risk; repeated samples; prospective longitudinal study; nested case-control study; circulating sEGFR and sERBB2; circulating immune markers and growth factors; marker disease association; disease progression; NSHDS; Janus; linear mixed modeling; epidemiologi; Epidemiology; Oncology; onkologi;

   Abstract : BACKGROUND: Nested case-control studies aim to link molecular markers with a certain outcome. Repeated prediagnostic samples may improve the evaluation of marker-disease associations. However, data regarding the benefit of repeated samples in such studies are sparse. READ MORE

7. 5. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

   Author : Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. READ MORE