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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

  2. 1. Regulators of chromatin and transcription in Drosophila

    Author : Filip Crona; Mattias Mannervik; Fernando Azorin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transcription; chromatin; co-regulators; CBP; lysine demethylase; KDM4A; Brakeless; Drosophila; utvecklingsbiologi; Developmental Biology;

    Abstract : Development of multicellular organisms is achieved by organized temporal and spatial patterns of gene expression leading to cell differentiation. Chromatin regulators control how the DNA is utilized by altering access of proteins to DNA and thereby function as co-factors in transcription. READ MORE

  4. 2. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1

    Author : Jie Yang; Jan Kihlberg; Morten Grötli; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; molecular recognition; peptide cyclization; protein targets;

    Abstract : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. READ MORE

  5. 3. The return of the nucleus : epigenetic regulation of autophagy

    Author : Jens Füllgrabe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autophagy is an evolutionary conserved catabolic process activated in response to a variety of cellular stresses, for example nutrient deprivation or chemotherapy. During autophagy, cells engulf parts of their cytplasm in a double-membrane vesicle, where misfolded proteins or damaged organelles are degraded. READ MORE

  6. 4. Dissecting gene expression regulation in mouse embryonic stems

    Author : Sandhya Malla; Francesca Aguilo; Filipe Pereira; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylärbiologi; Molecular Biology;

    Abstract : Every cell within an organism is derived from a single fertilized egg that undergoes cellular differentiation and development to generate mature specialized cells. Mouse embryonic stem cells (ESCs) derived from the inner cell mass (ICM) of the pre-implantation blastocyst have proven to be a model to study gene expression during differentiation and development. READ MORE

  7. 5. Studies on the regulation and function of lipoxygenases in Hodgkin lymphoma

    Author : Hongya Han; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hodgkin lymphoma (HL) is a unique entity among the lymphomas, with a minority of malignant Hodgkin and Reed-Sternberg (H-RS) cells surrounded by a broad range of infiltrating cells. The infiltration of certain inflammatory cells has been reported to predict prognosis of the disease. READ MORE