Search for dissertations about: "lysine demethylase"

Showing result 6 - 10 of 14 swedish dissertations containing the words lysine demethylase.

  2. 6. Short and long-term regulation of autophagy

    Author : Patricia González-Rodríguez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autophagy is a conserved catabolic pathway triggered by stress conditions in which portions of the cytoplasm, damage organelles, misfolded proteins and intracellular bacteria are delivered and degraded in the lysosome/vacuoles. Thus, an efficient induction and completion of the process is required to ensure a proper homeostasis of the cell. READ MORE

  4. 7. Gene regulation during development by chromatin and the Super Elongation Complex

    Author : Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

    Abstract : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. READ MORE

  5. 8. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads

    Author : Edward A. FitzGerald; Helena Danielson; Hanna-Kirsti Schrøder Leiros; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Drug Discovery; Biophysics; Fragment-based drug discovery; Epigenetics; Biosensors; Surface Plasmon Resonance; Interaction Analysis; Second-Harmonics; Biokemi; Biochemistry;

    Abstract : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. READ MORE

  6. 9. Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma

    Author : Xiaoying Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia. Genetic susceptibility, Epstein-Barr virus (EBV) infection and additional environmental exposures are well established risk factors for NPC in endemic areas. READ MORE

  7. 10. Deciphering microglia plasticity in glioma

    Author : Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE