Search for dissertations about: "müller cells"

Showing result 1 - 5 of 25 swedish dissertations containing the words müller cells.

  2. 1. Hormonal regulation of HES-1 in breast cancer cells

    Author : Patrick Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis and hematopoiesis. HES-1 has several well conserved domains, from Drosophila to mammals, and is expressed in a variety of tissues, in both embryos and adults. READ MORE

  4. 2. Organic dust from pig environment induces activation of human T cells

    Author : Charlotte Müller-Suur; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Organic dust; T cells; NK cells; cytokines; cellular activation;

    Abstract : Farmers suffer more frequently from inflammatory airway disorders than the population in general and a ongoing airway inflammation has been shown also in symptom-free healthy farmers. Exposure in a swine confinement building causes an intense airway inflammation with recruitment of inflammatory cells, predominately neutrophils, in healthy, previously, non-exposed subjects. READ MORE

  5. 3. Transcription factors regulating the Btk promoter

    Author : Susanne Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Btk; X-linked agammaglobulinemia; transcription factors; repression; synergism; Sp 1; Sp3; PU.l; Spi-B; genetherapy.;

    Abstract : Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase-related to the Src family of kinases. Mutations in various parts of the gene have been shown to lead to X-linked agammaglobulinemia, an immunodeficiency disease which is characterized by a defect in B-cell development. READ MORE

  6. 4. Bringing order to disorder : structural and functional analysis for development of strategies to target MYC

    Author : Inga Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated expression of MYC is present in a wide range of human tumors including Burkitt´s Lymphoma, neuroblastoma, medulloblastoma, colon cancer and glioblastoma. READ MORE

  7. 5. Apoptosis in chronic inflammation, with specific reference to airway disease

    Author : Malin Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Apoptosis; asthma; chronic inflammation; lung; sarcoidosis; tributyltin TBT ;

    Abstract : Mechanisms governing the normal resolution processes of inflammation in the lung are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of several pulmonary inflammatory disorders. The elimination of activated lymphocytes by apoptosis is one prerequisite for resolution, and knowledge concerning the role of apoptosis in chronic inflammation is still far from complete. READ MORE