Search for dissertations about: "mGluR5"

Showing result 1 - 5 of 15 swedish dissertations containing the word mGluR5.

  2. 1. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia

    Author : Tim Fieblinger; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Parkinson’s disease; L-DOPA-induced dyskinesia; ERK1 2; mGluR5; homeostatic plasticity; SPN; 2‑Photon microscopy;

    Abstract : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. READ MORE

  4. 2. Preclinical PET imaging of Alzheimer's disease progression

    Author : Xiaotian T. Fang; Stina Syvänen; Dag Sehlin; Lars Lannfelt; Merja Haaparanta-Solin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; transgenic mice; PET; antibody-based tracer; mGluR5; ABP688; di-scFv; amyloid-β;

    Abstract : Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]PIB is a small molecule that binds only the insoluble Aβ plaque. Rather, the soluble Aβ aggregates are considered the cause of Alzheimer’s disease (AD). READ MORE

  5. 3. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

    Author : Peter Bach; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mGluR5; P2Y12; gastroesophageal reflux disease GERD ; thrombosis; ethyl nicotinates; ureas; sulfonylureas; oxazoles; bioisosteres; regioselectivity; solvent effect.;

    Abstract : The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was developed to investigate the structure-activity relationships (SAR) of a novel series of 2-alkynylpyridine derivatives as mGluR5 antagonists. READ MORE

  6. 4. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes

    Author : Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

    Abstract : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. READ MORE

  7. 5. Studies on the plasticity of glutamate receptors and its role for neuronal calcium homeostasis

    Author : Linda Westin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Calcium is the most important and versatile signaling molecule in the brain. Neurons are equipped with a variety of tools to utilize this simple ion in diverse ways. From controlling the millisecond fast neurotransmitter release, to reshaping neuronal structure and function. READ MORE