Search for dissertations about: "mPGES-1"

Showing result 1 - 5 of 30 swedish dissertations containing the word mPGES-1.

  2. 1. mPGES-1 and the PGE2 pathway in arthritis

    Author : Marie Westman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prostaglandins; mPGES-1; PGES2; cyclooxygenase; rheumatoid arthritis; collagen induced arthritis; antirheumatic treatments; inflammation; synovial tissue; steroids; TNF blockade;

    Abstract : Prostaglandins are a group of lipid mediators derived from essential fatty acids that act on cells in close proximity of their synthesis. Prostaglandins are produced in a cell specific manner by a variety of cells in response to physiological or pathological stimulation. READ MORE

  4. 2. Prostaglandin E2 in Brain-mediated Illness Responses

    Author : Louise Elander; Anders Blomqvist; Marianne Schultzberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin e2; PGE2; cox-1; cox-2; mPGES-1; fever; anorexia; food intake; HPA-axis; EP-receptor; LPS; IL-1; IL-6; MEDICINE; MEDICIN; Neurobiology; Neurobiologi;

    Abstract : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. READ MORE

  5. 3. mPGES-1 : a key regulator of fever and neonatal respiratory depression

    Author : Sipra Saha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. READ MORE

  6. 4. Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition

    Author : Julia Steinmetz-Späh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and the microsomal prostaglandin E synthase 1 (mPGES-1). READ MORE

  7. 5. Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer

    Author : Filip Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E synthase-1 (mPGES-1). READ MORE