Search for dissertations about: "mPGES-1"

Showing result 16 - 20 of 30 swedish dissertations containing the word mPGES-1.

  2. 16. Studies of prostaglandin E2 formationin human monocytes

    Author : Sofia Karlsson; Jonny Wijkander; Christina Gustafson-Svärd; Karlstads universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin E2; arachidonic acid; phospholipase A2; cyclooxygenase; prostaglandin E synthase; human monocytes; Medical cell biology; Medicinsk cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. READ MORE

  4. 17. Prostaglandin modulation of airway hyperresponsiveness and inflammation in murine models of asthma

    Author : Linda Swedin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Allergic asthma is an inflammatory disease of the airways and is characterised by chronic inflammation, reversible bronchoconstriction and airway hyperresponsiveness (AHR). The cyclooxygenases (COXs) are key enzymes in the biosynthesis of prostaglandins, which have diverse physiological and pathological functions, and are also important modulators of inflammatory responses in the lung. READ MORE

  5. 18. Studies of the synovial membrane in chronic rheumatic joint disease

    Author : Erik af Klint; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: The synovial membrane (SM) outlines the inner cavity of synovial joints except for cartilage surfaces. The SM is the target organ of immune-mediated responses in chronic arthritis, including rheumatoid arthritis (RA). RA is a common joint disease (prevalence of 0.5-1. READ MORE

  6. 19. Apnea and infection in neonates : mediatory role of interleukin-1Beta and prostaglandin E2

    Author : Annika Olsson Hofstetter; Karolinska Institutet; Karolinska Institutet; []
    Keywords : respiration; interleukin-1Beta; prostaglandin E2; newborns; rodents; brainstem;

    Abstract : The breathing pattern of infants, particularly preterm infants, is often irregular or periodic and is frequently interrupted by apnea. The latter represents a major concern in haematology, yet much remains unknown about its incidence, appearance, and pathophysiology. READ MORE

  7. 20. Microcirculation in chronic kidney disease : from injury targets to potential therapeutics

    Author : Samsul Arefin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) is a major public health problem worldwide, and patients with end-stage kidney disease (ESKD) are at increased risk of developing cardiovascular complications. Small artery dysfunction is a common feature of CKD, which contributes to the development of early vascular ageing (EVA) and cardiovascular complications. READ MORE