Search for dissertations about: "mPGES-1"

Showing result 6 - 10 of 30 swedish dissertations containing the word mPGES-1.

  2. 6. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Author : Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). READ MORE

  4. 7. Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts

    Author : Manal Mustafa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Triclosan; gingival fibroblasts; IL-beta; IFN-gamma; MHC class II; PGE2; mPGES-1;

    Abstract : Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is a lipid soluble anti-bacterial agent widely used in dentifrices, mouthrinses, soap and cosmetics. Although reports on the efficacy of triclosan on periodontal diseases are conflicting, it is documented in clinical studies that dentifrices containing triclosan reduce plaque accumulation and improve gingival health. READ MORE

  5. 8. Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts

    Author : Tove Båge; Karolinska Institutet; Karolinska Institutet; []
    Keywords : c-Jun N-terminal kinase;

    Abstract : Periodontitis is a chronic inflammatory disease resulting in the destruction of the tissue and alveolar bone supporting the teeth and leading ultimately to tooth loss. Prostaglandin E2 (PGE2) is an important inflammatory mediator in the pathogenesis of periodontitis. READ MORE

  6. 9. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Author : Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. READ MORE

  7. 10. Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies

    Author : Anna Kats; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Periodontitis is a chronic inflammatory disease characterized by destruction of the supporting structures of the teeth, including gingival tissues and alveolar bone. In advanced cases of periodontitis the ultimate clinical outcome is tooth loss. READ MORE