Search for dissertations about: "mRNA decay"

Showing result 1 - 5 of 21 swedish dissertations containing the words mRNA decay.

  2. 1. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

    Author : Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

    Abstract : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. READ MORE

  4. 2. Microarray Analysis of mRNA Decay Assays and Prediction of Drug Target Conservation

    Author : Alexandra Jauhiainen; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microarray analysis; mRNA decay; evolutionary conservation; ecotoxicology; environmental risk assessments; ecotoxicology;

    Abstract : This thesis contains two papers concerning (I) the evolutionary conservation of drug targets and its potential use in environmental risk assessments and (II) mRNA degradation as a control mechanism during osmotic stress in the yeast S. cerevisiae. Environmental risk assessments are needed for the approval of new pharmaceutical compounds. READ MORE

  5. 3. Spatial control of mRNA stability in yeast

    Author : Susanne Huch; Tracy Nissan; Anders Byström; Anders Virtanen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mRNA stability; P bodies; mRNA turnover; gene regulation; decapping factors; molekylärbiologi; Molecular Biology;

    Abstract : The degradation of mRNA is an important modulator of gene expression and the ultimate fate of messenger mRNA. Important steps in the degradation of mRNA include initial shortening of its poly(A) tail followed by the subsequent removal of the m7G cap. These two processes are linked temporally as well as spatially. READ MORE

  6. 4. Regulation of pre-mRNA splicing and mRNA degradation in Saccharomyces cerevisiae

    Author : Yang Zhou; Marcus Johansson; Anders Byström; Marie Öhman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMD; RES complex; pre-mRNA splicing; magnesium homeostasis;

    Abstract : Messenger RNAs are transcribed and co-transcriptionally processed in the nucleus, and transported to the cytoplasm. In the cytoplasm, mRNAs serve as the template for protein synthesis and are eventually degraded. The removal of intron sequences from a precursor mRNA is termed splicing and is carried out by the dynamic spliceosome. READ MORE

  7. 5. Stability determinants and decay of Bacillus subtilis mRNAs

    Author : Gustav Hambraeus; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; bacteriology; Microbiology; Bacillus subtilis; mRNA stability; degradation;

    Abstract : Degradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. READ MORE