Search for dissertations about: "mRNA modifications"

Showing result 1 - 5 of 60 swedish dissertations containing the words mRNA modifications.

  2. 1. Accuracy of protein synthesis and its tuning by mRNA modifications

    Author : Gabriele Indrisiunaite; Måns Ehrenberg; Suparna Sanyal; Jaanus Remme; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein synthesis; Translation; Accuracy; Release factor; Termination; mRNA modifications; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : The ribosome is a large macromolecular complex that synthesizes all proteins in the cell in all kingdoms of life. Proteins perform many vital functions, ranging from catalysis of biochemical reactions to muscle movement. It is essential for cells and organisms that proteins are synthesized rapidly and accurately. READ MORE

  4. 2. Characterization of RNA exosome in Insect Cells : Role in mRNA Surveillance

    Author : Viktoria Hessle; Neus Visa; Maria Carmo-Fonseca; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell nucleus; nuclear bodies; mRNA surveillance; cotranscriptional assembly; Rrp6; Rrp4; mRNP; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : The exosome, an evolutionarily conserved protein complex with exoribonucleolytic activity, is one of the key players in mRNA quality control. Little is known about the functions of the exosome in metazoans. We have studied the role of the exosome in nuclear mRNA surveillance using Chironomus tentans and Drosophila melanogaster as model systems. READ MORE

  5. 3. Genotyping and Mutation Detection In Situ : Development and application of single-molecule techniques

    Author : Ida Grundberg; Mats Nilsson; Ulf Landegren; Olli-Pekka Kallioniemi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; padlock probes; in situ; rolling circle amplification; mRNA; genotyping; mutation detection; cancer; tissue sections; diagnostics; single-molecule; single-cell; microscopy; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

    Abstract : The human body is composed of trillions of cells closely working together to maintain a functional organism. Every cell is unique in molecular composition and can acquire genetic variations that might cause it to turn pathological. READ MORE

  6. 4. Exploring mTOR-dependent regulation of mRNA translation in cancer

    Author : Hui Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation step during mRNA translation. Subsets of transcripts are discriminated by structural and/or sequence features, and encode proteins involved in different biological functions. READ MORE

  7. 5. Functional aspects of wobble uridine modifications in yeast tRNA

    Author : Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. READ MORE