Search for dissertations about: "mRNA turnover"

Showing result 16 - 20 of 40 swedish dissertations containing the words mRNA turnover.

  2. 16. Regulation of cellular growth and identification of stromal gene signatures in breast cancer

    Author : Sofia Winslow; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; cellular stress; proliferation; PKCα; G3BP; PMP22; miR-34c; gene expression profiles; stroma;

    Abstract : Normal tissue is tightly controlled to keep a balance between reproduction and elimination of cells. In cancer, these regulated processes are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. READ MORE

  4. 17. Systems biology techniques show high prevalence of post-translational regulation in the cyanobacterium Synechocystis PCC 6803

    Author : Jan Karlsen; Elton Paul Hudson; Martin Hagemann; KTH; []
    Keywords : systems biology; sustainable development; omics; ribosome profiling; RNA sequencing; proteomics; genetic engineering; bioproduction; cyanobacteria; gene regulation; metabolism; translational regulation; post-translational regulation; bioinformatics; Bioteknologi; Biotechnology;

    Abstract : Earth's climate has been upset by carbon dioxide (CO2) emissions from human activities and the use of fossil resources. To prevent catastrophic events on the environment and on civilizations, we urgently need to develop alternative solutions that utilize renewable resources. READ MORE

  5. 18. Metabolic and endocrine function of human adipose tissue with focus on regional differences

    Author : Vanessa van Harmelen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : acylation stimulating protein; adipocytes; adipose tissue heterogeneity; adrenoceptors; insulin; leptin; lipogenesis; lipolysis; noradrenaline; plasminogen activator inhibitor-1; preadipocytes; tumour necrosis factor-cc;

    Abstract : The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also has a secretory function. READ MORE

  6. 19. Endocannabinoid metabolism : the impact of inflammatory factors and pharmacological inhibitors

    Author : Jessica Karlsson; Christopher Fowler; Stig Jacobsson; Jürg Gertsch; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

    Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE

  7. 20. The effects of glucocorticoids on brown fat : physiological and molecular studies

    Author : Ineke Luijten; Jan Nedergaard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Brown adipose tissue (BAT) is the main site for non-shivering thermogenesis in most mammals. The BAT-specific uncoupling protein-1 (UCP1) uncouples substrate oxidation from ATP production and hereby decreases metabolic efficiency. READ MORE