Search for dissertations about: "mRNA turnover"

Showing result 21 - 25 of 40 swedish dissertations containing the words mRNA turnover.

  2. 21. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes

    Author : Mi Huang; Genetisk och molekylär epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Obesity; Type 2 diabetes; CRISPR Cas9; precision medicine; adipocytes; functional genomics;

    Abstract : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. READ MORE

  4. 22. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models

    Author : Anita Koskela von Sydow; Mikael Ivarsson; Torbjörn Bengtsson; Hans Törmä; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

    Abstract : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. READ MORE

  5. 23. Bicuspid aortic valve-associated aortopathy unraveling the molecular signature

    Author : Valentina Paloschi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during aneurysm development is transforming growth factor-β (TGF-β) and impaired signaling of this pathway can alter important extracellular matrix (ECM) protein such us fibronectin and collagen and thereby explaining the increased aneurysm susceptibility of BAV patients. READ MORE

  6. 24. Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma

    Author : Malin Hakelius; Daniel Nowinski; Bengt Gerdin; Kristofer Rubin; Avni Abdiu; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coculture; extracellular matrix; interleukin-1 alpha; tumor stroma; differential gene regulation; innate response; Plastic Surgery; Plastikkirurgi;

    Abstract : Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. READ MORE

  7. 25. Novel Regulators of the TGF-β Signaling Pathway

    Author : Marcin Kowanetz; Aristidis Moustakas; Carl-Henrik Heldin; Caroline Hill; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; Smad; Id; EMT; cell cycle; SNF1LK; ubiquitin; degradation; signal transduction; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. READ MORE